What are the symptoms of congenital analgesia?

What are the symptoms of congenital analgesia?

Congenital insensitivity to pain with anhidrosis (CIPA) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis). This condition is also known as hereditary sensory and autonomic neuropathy type IV.

What does congenital analgesia affect?

Congenital insensitivity to pain is considered a form of peripheral neuropathy because it affects the peripheral nervous system, which connects the brain and spinal cord to muscles and to cells that detect sensations such as touch, smell, and pain.

Can CIPA patients taste?

Since the abilities of CIPA patients to perceive taste and smell were not basically impaired, despite their lower sensitivity to capsaicin, it was suggested that their dietary habits were only minimally affected, except for intake of pungent foods.

How is CIPA caused?

CIPA is caused by mutations in the NTRK1 gene , which gives the body instructions to make a protein that is important for the development and survival of nerve cells – especially those that carry information about pain, temperature, and touch (sensory neurons).

How is congenital analgesia causes?

Congenital insensitivity to pain is caused by mutations in the SCN9A gene and, in rare cases, is caused by mutations in the PMRD12 gene. It is inherited in an autosomal recessive pattern.

What is congenital analgesia?

Congenital insensitivity to pain (CIP), also known as congenital analgesia, is one or more extraordinarily rare conditions in which a person cannot feel (and has never felt) physical pain.

What causes congenital analgesia?

Can CIPA patients cry?

Lack of Pain: Most people who have CIPA do not complain of lack of pain or lack of sweat. Instead, children with CIPA initially experience injuries or burns without crying, complaining, or even noticing. Parents may observe that a child with CIPA is just a mild-mannered kid, rather than noticing a problem.

Can CIPA patients smell?

Actually, they wouldn’t know because people with congenital insensitivity to pain can’t smell anything. Researchers have discovered that these individuals who have a rare genetic condition rendering their lives pain-free also don’t have a sense of smell.

How long can CIPA patients live?

While some reports indicate that these patients can only live up to five years and predict a poor prognosis for this disorder [4, 18, 19, 20], all of our patients were older. The reasons for death among patients with CIPA are things that could otherwise be treated.

How common is congenital analgesia?

Congenital insensitivity to pain is a rare condition; about 20 cases have been reported in the scientific literature.

What are the causes of congenital analgesia?

What is congenital insensitivity to pain with anhidrosis?

Collapse Section Congenital insensitivity to pain with anhidrosis (CIPA) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis). This condition is also known as hereditary sensory and autonomic neuropathy type IV.

What does it mean to have congenital analgesia?

Congenital Analgesia Congenital insensitivity to pain is suggested in an infant or young child presenting with a history of multiple traumas (e.g., burns, abrasions) that are unnoticed by the patient and, at least initially, also by the parents or guardians. From: Clinical Imaging (Third Edition), 2014

What causes congenital insensitivity to pain ( CIPA )?

Congenital Insensitivity to Pain with Anhidrosis (CIPA) or HSAN IV is an AR disorder caused by mutations in NTRK1 (neurotrophic tyrosine kinase, receptor type) ( Indo et al., 1996 ).

Is it necessary to have an anesthetic for congenital insensitivity?

Despite congenital insensitivity to pain, general anesthesia was found to be necessary. Overall requirements of general anesthetics necessary for maintaining stable hemodynamics have been only slightly reduced.

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