How do you administer IV daptomycin?
How do you administer IV daptomycin?
CUBICIN should be administered intravenously either by injection over a two (2) minute period or by infusion over a thirty (30) minute period. CUBICIN 4 mg/kg should be administered intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
How do you give daptomycin?
In adults, Daptomycin is given by intravenous infusion (see section 6.6) and administered over a 30-minute period or by intravenous injection (see section 6.6) and administered over a 2-minute period.
How long does it take to reconstitute daptomycin?
The combined storage time (reconstituted solution in vial and diluted solution in infusion bag) should not exceed 12 hours at room temperature or 48 hours under refrigeration. CUBICIN is compatible with 0.9% sodium chloride injection and lactated Ringer’s injection.
Is daptomycin dosed on actual body weight?
Background: Food and Drug Administration-approved daptomycin dosing uses actual body weight, despite limited dosing information for obese patients. Studies report alterations in daptomycin pharmacokinetics and creatine phosphokinase elevations associated with higher weight-based doses required for obese patients.
What is the pH of daptomycin?
The pH of the solution upon reconstitution is 6.8. Freshly reconstituted solutions of CUBICIN RF range in color from pale yellow to light brown.
What weight do you use for daptomycin dosing?
When obtaining Food and Drug Administration (FDA) approval, daptomycin was dosed at 4–6 mg/kg of actual body weight (ABW) based on indication. However, obese patients with a BMI ⩾30 mg/m2 were not well represented in the clinical trials.
Is acyclovir dosed on ideal body weight?
The manufacturer recommends calculation of intravenous (i.v.) acyclovir dose to be based on total body weight (TBW); however, in obese patients it recommends dosing by ideal body weight (IBW) (3).
How do you mix IV linezolid?
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- The liquid form of linezolid should be gently mixed by turning the bottle upside down 3 to 5 times before each dose. Do not shake this product.
- Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup.
- Do not use after the expiration date on the label.
How do you administer Zyvox IV?
ZYVOX I.V. Injection should be administered by intravenous infusion over a period of 30 to 120 minutes. Do not use this intravenous infusion bag in series connections. Additives should not be introduced into this solution.
How much does daptomycin cost?
This daptomycin price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for daptomycin intravenous powder for injection 350 mg is around $241 for a supply of 1 powder for injection, depending on the pharmacy you visit.
Why can’t daptomycin be used for pneumonia?
Daptomycin is not used for pneumonia for various reasons. It binds to pulmonary surfactant and hence cannot be used in the treatment of pneumonia. Also, Daptomycin is generally used for things like multi resistant Staphylococcus and Enterococcus infections which are not the usual organisms for pneumonia.
Does daptomycin cause nephrotoxicity?
Compared to other antibiotics with a similar antibacterial spectrum, daptomycin does not cause nephrotoxicity. Taking these and other characteristics into consideration, daptomycin appears to be a good alternative to other drugs used in the treatment of complicated skin and soft tissue infections and in Gram-positive bacteremial infections.
Is daptomycin expensive?
♦ Data on dosing and safety are lacking in patients with kidney impairment. ♦ The drug cost for daptomycin ( Cubicin ) is $165 per day. This is more expensive than other alternative treatments such as vancomycin ($92.54), cloxacillin ($0.70-$14.40) and linezolid ($141.28).