What class of drugs is cinacalcet?
What class of drugs is cinacalcet?
Cinacalcet is in a class of medications called calcimimetics. It works by signaling the body to produce less parathyroid hormone in order to decrease the amount of calcium in the blood.
Is cinacalcet a phosphate binder?
Phosphate Binders Cinacalcet is a type II calcimimetic agent that binds the trans-membrane region of the calcium-sensing receptor, resulting in allosteric modulation. The change in receptor configuration makes it more sensitive to serum calcium and results in a reduction of serum PTH at lower levels of serum calcium.
What is the mechanism of action of cinacalcet?
Mechanism of Action Cinacalcet is an oral calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium. The calcium-sensing receptors on the surface of parathyroid gland cells also regulate parathyroid hormone (PTH) secretion.
Why is cinacalcet used in secondary hyperparathyroidism?
Cinacalcet effectively reduced parathyroid hormone levels independently of disease severity or changes in vitamin D sterol dose. Conclusions: Cinacalcet lowers parathyroid hormone levels and improves calcium-phosphorus homeostasis in patients receiving hemodialysis who have uncontrolled secondary hyperparathyroidism.
Why is cinacalcet used in CKD?
Cinacalcet hydrochloride (Amgen, Thousand Oaks, CA, United States) is a type II calcimimetic that increases the sensitivity to extracellular calcium of the calcium-sensing receptor (CaR) located in chief cells of parathyroid gland, thereby reducing PTH synthesis and release [4].
Does cinacalcet increase calcium?
Cinacalcet enhances the sensitivity of the CaSR to the prevailing extracellular calcium, resulting in an increase in the intracellular calcium concentration and a concomitant reduction in PTH released by the parathyroid gland.
Does cinacalcet increase phosphorus?
Cinacalcet reduced calcium values and increased phosphorus values, as can be seen in Figs 2 and 3. At baseline, the mean calcium value was 9.7 ± 0.7 mg/dl, which was reduced by 4% and 6% at 3 and 12 months respectively.
What is Renvela 800 for?
Renvela (sevelamer) is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus. Renvela is used to control phosphorus levels in people with chronic kidney disease who are on dialysis.
What is cinacalcet 30 mg?
Cinacalcet is used to treat increased amounts of a certain hormone (parathyroid) in people with long-term kidney disease who are on dialysis. It is also used to treat increased amounts of calcium in people with an overactive parathyroid gland or in people with cancer of the parathyroid gland.
Does cinacalcet increase blood pressure?
In adjusted models, at 20 weeks cinacalcet resulted in a 2.2 mm Hg larger average decrease in systolic blood pressure (P=0.002) and a 1.3 mm Hg larger average decrease in diastolic blood pressure (P=0.002) compared with placebo.
Can cinacalcet cause low blood pressure?
Your doctor will order important blood tests while you are taking this medicine. This medicine may cause an increase or decrease in your blood pressure. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.